路易,罗乙娲,焦树强

• 1:北京科技大学绿色低碳钢铁冶金全国重点实验室

摘要(Abstract)：

钛合金具有硬度高，耐磨损，生物相容性好等优点，在骨科植入物和骨组织修复领域的应用越来越广泛。但是，未经处理的钛合金表面通常表现出较差的细胞黏附性，不利于骨整合。为了激发钛合金材料的生物活性，需要对其表面进行改性处理。本研究采用碱热处理（AHT）的方式对由激光粉末床熔合技术（LPBF）制备的多孔Ti6Al4V合金材料进行表面改性，考察了碱溶液浓度和处理时间对钛合金材料表面形貌的影响，并对表面改性后的试样进行了生物相容性测试。结果表明，试样经过酸洗预处理后，在60℃恒温条件下浸泡于7 mol/L NaOH溶液中并保温1 h，经过高温烧结得到的试样表面形成了形态良好、分布均匀的纳米网状钛酸钠涂层，再经过模拟体液浸泡培养10 d，形成磷灰石涂层。采用直接接触的方式将骨髓间充质干细胞（hBMSC）接种在试样上，培养48 h，测得碱热处理且经过模拟体液浸泡试样的细胞相对活性明显高于未经处理的试样。

关键词(KeyWords)： 钛合金;碱热处理;生物活性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金项目（52004026）;; 中央高校基本科研业务费项目（FRF-TP-22-012A1）

作者(Author): 路易,罗乙娲,焦树强

DOI: 10.19864/j.cnki.jxye.2024.02.007

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